• Latest
  • Trending
  • All
  • News
  • Business
  • Politics
  • World
  • Tech
Coronavirus: two vaccines enter human trials, 60 in pre-clinical stage

Coronavirus: two vaccines enter human trials, 60 in pre-clinical stage

11 months ago
Sarmad reviews arrangements for tourists at Patnitop

Sarmad reviews arrangements for tourists at Patnitop

1 week ago
Advisor Baseer Khan reviews Shivratri arrangements

Advisor Baseer Khan reviews Shivratri arrangements

1 week ago
Krishna Dhaba attack worked out within 48 hours: Police

Krishna Dhaba attack worked out within 48 hours: Police

1 week ago
BJP Media Secretary joins Apni Party in presence of Altaf Bukhari

BJP Media Secretary joins Apni Party in presence of Altaf Bukhari

1 week ago
COVID-19 PANDEMIC: No respite in Valley

81 new COVID cases in J&K

1 week ago
HDFC Bank and Red FM launch “Talent Unlocked”

HDFC Bank and Red FM launch “Talent Unlocked”

1 week ago
JKCA selectors are outsiders, no role of Parvez Rasool in functioning of JKCA, player selection: Ashiq Bukhari

JKCA selectors are outsiders, no role of Parvez Rasool in functioning of JKCA, player selection: Ashiq Bukhari

1 week ago
PAGD won highest seats in DDC elections but manages to make chairpersons only in 5 districts

PAGD wins DDC chairperson posts in two Jammu districts

1 week ago
Dir Tourism reviews dev, infrastructure facilities at pilgrim sites

Dir Tourism reviews dev, infrastructure facilities at pilgrim sites

1 week ago
Lt Governor holds interaction with Foreign Envoys

Lt Governor holds interaction with Foreign Envoys

1 week ago
Govt asks All Employees to attend Offices from June 6

e-Kuber payments system launched in J&K

1 week ago
Mehbooba Mufti shifted to her residence, detention continues

Our demand is restoration of special status of J&K not Statehood, says Mehbooba in Kupwara

1 week ago
  • About
  • Privacy Policy
  • Contact
Saturday, February 27, 2021
4 °c
Srinagar
6 ° Sun
5 ° Mon
7 ° Tue
7 ° Wed
6 ° Thu
  • Login
Kashmir Reporter
  • News
    Krishna Dhaba attack worked out within 48 hours: Police

    Krishna Dhaba attack worked out within 48 hours: Police

    BJP Media Secretary joins Apni Party in presence of Altaf Bukhari

    BJP Media Secretary joins Apni Party in presence of Altaf Bukhari

    HDFC Bank and Red FM launch “Talent Unlocked”

    HDFC Bank and Red FM launch “Talent Unlocked”

    PAGD won highest seats in DDC elections but manages to make chairpersons only in 5 districts

    PAGD wins DDC chairperson posts in two Jammu districts

    Dir Tourism reviews dev, infrastructure facilities at pilgrim sites

    Dir Tourism reviews dev, infrastructure facilities at pilgrim sites

    Cyber Police Station Kashmir Zone traced/recovered Smart-phones worth lacs of rupees

    Cyber Police Station Kashmir Zone traced/recovered Smart-phones worth lacs of rupees

    DAK urges doctors to prescribe generic drugs

    Covid-19 vaccine more effective with second dose at 12 weeks: DAK

    Mansoor Hussain Sohrawardhy resigns from PDP’s basic membership

    Mansoor Hussain Sohrawardhy resigns from PDP’s basic membership

    J&K MEGA welcome Govt. initiatives to address pending demands of engineers

    J&K MEGA welcome Govt. initiatives to address pending demands of engineers

    PAGD won highest seats in DDC elections but manages to make chairpersons only in 5 districts

    PAGD won highest seats in DDC elections but manages to make chairpersons only in 5 districts

  • Politics
  • World
  • Business
  • Opinion
  • Sports
  • COVID19
No Result
View All Result
Kashmir Reporter
No Result
View All Result
Home News

Coronavirus: two vaccines enter human trials, 60 in pre-clinical stage

by KR Newsdesk
April 12, 2020
in News
2 min read
Coronavirus: two vaccines enter human trials, 60 in pre-clinical stage
173
SHARES
207
VIEWS
Share on FacebookShare on TwitterShare on WhatsApp

With the genetic information of the novel coronavirus (SARS-CoV-2) available online, governments across the globe, top private players, academics and not-for-profit organisations are working at a breakneck pace to find a COVID-19 vaccine.

According to the “DRAFT landscape of COVID-19 candidate vaccines” released by the World Health Organization (WHO) on April 4, two vaccines are currently being tested on humans.

This includes a non-replicating viral vector vaccine developed by CanSino Biological Inc. along with the Beijing Institute of Biotechnology. A non-replicating vector vaccine can be developed either using a virus that is killed or a part of the virus. Since it is not a complete virus, it cannot replicate inside the host; but the antigens trigger our immune system to produce antibodies, which help fight the disease in case we contract it in the future.

Also read: South Korea to Impose Tracking Wristband for Defying Quarantine Orders

RNA vaccine

According to the Chinese Clinical Trial Registry, men and women between the ages of 18 and 60 were recruited and tests are being conducted on three groups of 36 participants each. Three dosages are being tested — low, medium and high.

The second is a messenger RNA vaccine developed by Moderna and National Institute of Allergy and Infectious Diseases. In RNA vaccines, the messenger RNA from the pathogen is used. The messenger RNA gets translated into antigenic protein recognised by our immune cells and antibodies are produced. But mRNA is a highly unstable molecule making it difficult to handle. So the mRNA is encapsulated in a small ball of fat or lipid nanoparticle (LNP). This LNP acts as a delivery vehicle that helps the mRNA cross the host cell membrane and once inside the mRNA is released.

According to the website clinicaltrials.gov, forty-five subjects (18 to 55 years of age of both sexes) will be enrolled and divided into three groups. They will receive an intramuscular injection on days 1 and 29 in the deltoid muscle.

An analysis published on April 9 in Nature Reviews Drug Discovery by the Coalition for Epidemic Preparedness Innovations (CEPI) notes that “the global COVID-19 vaccine R&D landscape includes 115 vaccine candidates, of which 78 are confirmed as active and 37 are unconfirmed (development status cannot be determined from publicly available or proprietary information sources).” Along with the two vaccines mentioned by WHO, the list includes one vaccine developed by Inovio Pharmaceuticals and two from Shenzhen Geno-Immune Medical Institute.

Vaccines from India

The WHO draft adds that 60 candidate vaccines are in preclinical trials. This list contains the DNA plasmid vaccine developed by Gujarat based Zydus Cadila and Live Attenuated Virus vaccine developed by the Serum Institute of India.

DNA vaccines are made by taking genes from the pathogen and inserting it into the host’s body with a vector. The host cells produce the protein of the viral gene and this is recognised as a foreign antigenic protein by the host’s immune system.

DNA vaccines are comparatively easy to make, transport, store and are cheaper. Live attenuated virus vaccine is created by reducing the virulence of a pathogen or weakening it, but still keeping it alive.

Tags: COVID19
Share130Tweet18Send
  • Trending
  • Comments
  • Latest
Pakistani cricketer Shahid Afridi visits Hindu temple with food supply amidst COVID-19 pandemic; Yuvraj Singh had supported his initiative

Pakistani cricketer Shahid Afridi visits Hindu temple with food supply amidst COVID-19 pandemic; Yuvraj Singh had supported his initiative

May 13, 2020
Meet Ustaz Nafis Yaakub, the boy who used to recite the Quran in prison!

Meet Ustaz Nafis Yaakub, the boy who used to recite the Quran in prison!

May 16, 2020
MGNREGA supporting staff awaits absorption ‘Following a proper mechanism: Advisor

MGNREGA supporting staff awaits absorption ‘Following a proper mechanism: Advisor

June 27, 2020
Sarmad reviews arrangements for tourists at Patnitop

Sarmad reviews arrangements for tourists at Patnitop

All traders from Magarmal Bagh stage protest against administration, demands rehabilitation.

All traders from Magarmal Bagh stage protest against administration, demands rehabilitation.

JK students dominate in Aryans Chandigarh Academic results

JK students dominate in Aryans Chandigarh Academic results

Sarmad reviews arrangements for tourists at Patnitop

Sarmad reviews arrangements for tourists at Patnitop

February 19, 2021
Advisor Baseer Khan reviews Shivratri arrangements

Advisor Baseer Khan reviews Shivratri arrangements

February 19, 2021
Krishna Dhaba attack worked out within 48 hours: Police

Krishna Dhaba attack worked out within 48 hours: Police

February 19, 2021
Kashmir Reporter

© 2020 Kashmir Reporter.

Navigate Site

  • About
  • Privacy Policy
  • Contact

Follow Us

No Result
View All Result
  • Home
  • COVID19
  • News
  • Politics
  • World
  • Opinion
  • Business
  • Sports

© 2020 Kashmir Reporter.

Welcome Back!

Login to your account below

Forgotten Password?

Create New Account!

Fill the forms bellow to register

All fields are required. Log In

Retrieve your password

Please enter your username or email address to reset your password.

Log In
This website uses cookies. By continuing to use this website you are giving consent to cookies being used. Visit our Privacy and Cookie Policy.